TY - CHAP M1 - Book, Section TI - Fragile X Syndrome A1 - Bissonnette, Bruno A1 - Luginbuehl, Igor A1 - Engelhardt, Thomas PY - 2019 T2 - Syndromes: Rapid Recognition and Perioperative Implications, 2e AB - Most common form of X-linked mental retardation. Symptoms most often are limited to mild to moderate intellectual disability. Affects males more often and more severely than females. The clinical presentation is delayed development of speech and language by age 2. Physical features may include a long and narrow face, large ears, flexible fingers, and large testicles (macroorchidism) after puberty. In a third of people behavioral features include autism-like signs such as problems with social interactions and delayed speech. Hyperactivity is common and seizures occur in about 10%. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1164070247 ER -