TY - CHAP M1 - Book, Section TI - Glanzmann’s Thrombasthenia A1 - Bissonnette, Bruno A1 - Luginbuehl, Igor A1 - Engelhardt, Thomas PY - 2019 T2 - Syndromes: Rapid Recognition and Perioperative Implications, 2e AB - Genetic platelet disorder resulting in blood clotting disorder and hemorrhage. The disease is usually diagnosed in young ages after epistaxis or mucocutaneous bleeding. Complaints such as easy bruising, muscle hematomas, hemarthrosis gastrointestinal bleeding, menorrhagia, and hematuria appear in further stages of life. This medical condition is associated with life-threatening conditions when the patient is exposed to stress (eg, surgery, anesthesia). It is an extremely rare coagulopathy disorder in which the platelets contain defective or low levels of glycoprotein IIb/IIIa (GpIIb/IIIa), which is a receptor for fibrinogen. As a result, no fibrinogen bridging of platelets to other platelets can occur, and the bleeding time is significantly prolonged. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/03 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1164070857 ER -