TY - CHAP M1 - Book, Section TI - Hemophilia B A1 - Bissonnette, Bruno A1 - Luginbuehl, Igor A1 - Engelhardt, Thomas PY - 2019 T2 - Syndromes: Rapid Recognition and Perioperative Implications, 2e AB - Hereditary coagulation disorder caused by defective synthesis of plasma protein factor IX. It is the second-most common form of hemophilia, rarer than hemophilia A. The clinical hallmark of hemophilia B is articular hemorrhage. This bleeding is painful and leads to long-term inflammation and deterioration of the articulation. It is typically present in children and affects the ankles, whereas it more often involves the knees and elbows in adolescents and adults. These complications results in permanent articular deformities, misalignment, loss of mobility, and lead to extremities of unequal lengths. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/07 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1164072450 ER -