TY - CHAP M1 - Book, Section TI - Lissencephaly A1 - Bissonnette, Bruno A1 - Luginbuehl, Igor A1 - Engelhardt, Thomas PY - 2019 T2 - Syndromes: Rapid Recognition and Perioperative Implications, 2e AB - It is a group of disorders that is associated with incomplete neuronal migration during the period of brain development at 9 to 24 weeks’ gestation. It is characterized by the absence of sulcation of the cerebral hemispheres resulting in smooth brain surface (absence of gyri). The name comes from the Greek lissos (smooth) and enkephale (brain). It involves the whole or parts of the surface of the brain. Clinically, it is characterized by microcephalia, severe psychomotor retardation, failure to thrive, intractable seizures, muscle spasticity, and hypotonia. The onset of the symptoms varies with age and the type of disorder. Life expectancy is often shortened due to respiratory complications. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1164077030 ER -