TY - CHAP M1 - Book, Section TI - Marfan Syndrome A1 - Bissonnette, Bruno A1 - Luginbuehl, Igor A1 - Engelhardt, Thomas PY - 2019 T2 - Syndromes: Rapid Recognition and Perioperative Implications, 2e AB - It is a familial disorder characterized by generalized connective tissue abnormalities leading to abnormal tissue weakness with hyperextensible joints, eyes (dislocation of the lens), increased risk of acute aortic valve dissection, and spontaneous pneumothorax. The leading cause of mortality in the infancy period is the progression from mitral valve prolapse to acute regurgitation, often in conjunction with tricuspid regurgitation, leading to congestive heart failure and death. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1164077765 ER -