TY - CHAP M1 - Book, Section TI - Allergy and Asthma A1 - Capucilli, Peter A1 - Brown-Whitehorn, Terri A2 - Shah, Samir S. A2 - Ronan, Jeanine C. A2 - Catallozzi, Marina A2 - Frank, Gary PY - 2022 T2 - The Philadelphia Guide: Inpatient Pediatrics, 3e AB - Anaphylaxis is an acute, potentially life-threatening systemic allergic reaction. It is most commonly triggered by interaction of an allergen with specific IgE antibody bound to mast cells and basophils, leading to cell activation and mediator release. Non–IgE-mediated direct mast-cell degranulation can also result in mediator release. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/04/24 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1185342329 ER -