TY - CHAP M1 - Book, Section TI - Central Nervous System Involvement and Risk of Neurodevelopmental Delay inĀ Fetuses with Congenital Heart Disease A1 - Paladini, Dario A1 - Birnbaum, Roee A2 - Malinger, Gustavo A2 - Monteagudo, Ana A2 - Pilu, Gianluigi A2 - Paladini, Dario A2 - Timor-Tritsch, Ilan E. PY - 2023 T2 - Timor's Ultrasonography of the Prenatal Brain, 4e AB - KEY POINTSIt is well established that congenital heart disease (CHD) in general, and lesions resulting in a univentricular circulation in particular, are associated with increased risk for neurodevelopmental impairments.Although still an emerging field in prenatal diagnosis, accumulating data shows that the CHD itself is responsible for brain abnormalities such as periventricular leukomalacia (PVL), migration abnormalities or biometric problems.The pathogenetic mechanism for these abnormalities may involve, at least in part, hemodynamic changes, and fetal genetic conditions.Neurosonography is indicated in fetuses with CHD, in order to rule out associated CNS malformations (such as sulcation and gyration abnormalities), and/or acquired lesions. SN - PB - McGraw Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1194721663 ER -