TY  - CHAP
M1  - Book, Section
TI  - Chapter 40. Fetal Disorders
A1  - Lim, Timothy M. Crombleholmeand Foong-Yen
A2  - Rudolph, Colin D.
A2  - Rudolph, Abraham M.
A2  - Lister, George E.
A2  - First, Lewis R.
A2  - Gershon, Anne A.
PY  - 2011
T2  - Rudolph's Pediatrics, 22e
AB  - The  combination  of  extraordinary  advances  in  molecular  genetics,  prenatal  genetic  diagnosis,1  and  the  continuous  technologic  innovations  in  prenatal  imaging2,3  now  make  it  possible  to  diagnose  prenatally  virtually  any  condition  with  high  levels  of  confidence.  This  capability  has  afforded  the  opportunity  to  consider  prenatal  treatment  for  an  ever-expanding  list  of  conditions  that  in  years  past  depended  on  postdelivery  assessments.  In  many  instances,  irreparable  organ  injury  or  even  death  occurred  as  a  result  of  this  delay.  Fetal  therapy  holds  significant  promise  to  change  the  natural  history  and  improve  not  only  perinatal  survival  but  long-term  outcomes  as  well.4  Fetal  therapy  has  expanded  the  conditions  that  may  be  considered  for  medical  treatment,  including  congenital  pulmonary  airway  malformations  (CPAM),5,6  fetal  arrhythmias,7  congenital  adrenal  hyperplasia,8  and  even  congenital  diaphragmatic  hernia.9-11  Possible  indications  for  open  fetal  surgery  have  broadened  to  conditions  such  as  myelomeningocele,12  sacrococcygeal  teratoma,13,14  bladder  outlet  obstruction,15,16  and  CPAM.6  But  perhaps  the  most  striking  area  of  growth  in  fetal  intervention  is  for  conditions  that  may  be  treated  by  fetoscopic  techniques,17  such  as  twin-twin  transfusion  syndrome,17-20  twin  reversed  arterial  perfusion  sequence,21,22  and  congenital  diaphragmatic  hernia.9-11  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/18
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=6734001
ER  -