TY - CHAP M1 - Book, Section TI - Chapter 102. Respiratory Distress and Failure A1 - FontáN, Julio PéRez A2 - Rudolph, Colin D. A2 - Rudolph, Abraham M. A2 - Lister, George E. A2 - First, Lewis R. A2 - Gershon, Anne A. PY - 2011 T2 - Rudolph's Pediatrics, 22e AB - In healthy individuals, respiratory and circulatory functions are linked to tissue metabolic activity by a responsive regulatory system that translates biochemical and neural signals from the tissues into adjustments in cardiac output, vascular tone, and minute ventilation. The purpose of this system is to assure that all the cells in the organism receive a supply of O2 commensurate with their metabolic needs without accumulating excessive amounts of CO2. The system relies both on local circulatory reflexes, which alter the caliber of the supplying blood vessels in accordance with tissue metabolic activity, and on central circulatory and respiratory reflexes, which adjust the pumping function of the heart and the intensity of the respiratory effort in response to changes in the concentration of the respiratory gases in the blood.1 SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/24 UR - accesspediatrics.mhmedical.com/content.aspx?aid=6720244 ER -