TY - CHAP M1 - Book, Section TI - Chapter 143. Disorders of Amino Acid Transport Across Cell Membranes A1 - Näntö-Salonen, Kirsti A1 - Simmell, Ollie A2 - Rudolph, Colin D. A2 - Rudolph, Abraham M. A2 - Lister, George E. A2 - First, Lewis R. A2 - Gershon, Anne A. PY - 2011 T2 - Rudolph's Pediatrics, 22e AB - Epithelial cells in such places as renal tubules and intestinal mucosa utilize several different transport systems that move amino acids through the luminal (apical) and the antiluminal (basolateral) membranes of the cell in functional cooperation, utilizing sodium-dependent symporters, proton-motive forces, and concentration gradients of other amino acids. Each system prefers groups of amino acids with certain physicochemical properties, but most individual amino acids can use more than one transporter. The transport activities have been classified in five main groups: (1) the “basic system” for cystine and the structurally related dibasic cationic amino acids lysine, arginine, and ornithine; (2) the “neutral system” for neutral amino acids; (3) the “acidic system” for glutamate and aspartate; (4) the “iminoglycine system” for proline, hydroxyproline, and glycine; and (5) the “beta-amino acid system.” SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=6725486 ER -