TY - CHAP M1 - Book, Section TI - Chapter 164. Disorders of Cholesterol Synthesis A1 - Clayton, Peter T. A2 - Rudolph, Colin D. A2 - Rudolph, Abraham M. A2 - Lister, George E. A2 - First, Lewis R. A2 - Gershon, Anne A. PY - 2011 T2 - Rudolph's Pediatrics, 22e AB - The isoprenoid synthesis pathway (Fig. 164-1) leads to the synthesis of cholesterol (an important constituent of cell membranes and a precursor of steroid hormones and bile acids), haem A (a component of complex IV of the respiratory chain), ubiquinone (an electron carrier in the respiratory chain), dolichol (which is required for glycosylation of proteins), farnesyl-pyrophosphate, and geranylgeranyl-pyrophosphate (which are important for prenylation of proteins).1 Prenylation of proteins is important in many signaling cascades in the cell. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/10/15 UR - accesspediatrics.mhmedical.com/content.aspx?aid=6727156 ER -