TY  - CHAP
M1  - Book, Section
TI  - Chapter 246. Antibacterial Therapy
A1  - Hong, David K.
A1  - Prober, Charles G.
A2  - Rudolph, Colin D.
A2  - Rudolph, Abraham M.
A2  - Lister, George E.
A2  - First, Lewis R.
A2  - Gershon, Anne A.
PY  - 2011
T2  - Rudolph's Pediatrics, 22e
AB  - The  first  antibiotic  to  be  discovered  was  penicillin,  a  natural  product  of  Penicillium  mold.  Innumerable  microbial  products  have  been  investigated  since  then,  and  much  work  has  been  done  in  chemically  modifying  these  natural  products  in  an  attempt  to  enhance  the  benefits  while  minimizing  the  undesirable  effects.  These  modified  products,  termed  semisynthetic  antibiotics,  increased  stability  and  solubility,  improved  pharmacokinetics  (ie,  wider  distribution  and  longer  half-life),  and  increased  antimicrobial  activity.  Minimizing  the  undesirable  effects  creates  antibiotics  with  decreased  toxicity  and  increased  efficacy.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/19
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=7024560
ER  -