TY  - CHAP
M1  - Book, Section
TI  - Chapter 307. Hemorrhagic Fevers
A1  - Farnon, Eileen C.
A1  - Ksiazek, Thomas G.
A1  - Khan, ALI S.
A2  - Rudolph, Colin D.
A2  - Rudolph, Abraham M.
A2  - Lister, George E.
A2  - First, Lewis R.
A2  - Gershon, Anne A.
PY  - 2011
T2  - Rudolph's Pediatrics, 22e
AB  - Viral  hemorrhagic  fever  is  a  severe,  sometimes  fatal,  multisystem  syndrome  characterized  by  diffuse  vascular  damage  and  dysregulation;  hemorrhage  does  not  necessarily  occur;  when  it  does,  it  is  rarely  a  sufficient  cause  for  demise.  The  etiologic  agents  of  this  syndrome  are  zoonotic,  lipid-enveloped  ribonucleic  acid  (RNA)  viruses  and  include  dozens  of  members  from  4  families  of  viruses:  arenaviruses,  bunyaviruses,  filoviruses,  and  flaviviruses  (Table  307-1).  These  agents  are  localized  geographically  and  are  associated  with  specific  vector  hosts  or  reservoirs,1-5  although  imported  cases  and  infections  caused  by  laboratory  accidents  and  nosocomial  transmission  can  occur  outside  their  respective  ranges.6  The  diseases  they  cause  are  either  endemic  or  episodic  with  both  annual  cycles  and  longer  secular  trends.  Some  are  associated  with  high  lethality  and  potential  for  person-to-person  transmission.  The  challenges  for  clinicians  evaluating  suspect  cases  are  to  exclude  more  likely  conditions  that  are  potentially  life-threatening  and  treatable  (especially  malaria  and  typhoid  fever);  narrow  the  differential  diagnosis  based  on  the  travel  history;  institute  appropriate  precautions  for  the  diseases  in  the  narrowed  differential  that  are  associated  with  person-to-person  transmission;  and  seek  expert  guidance  for  diagnostic  confirmation  and  treatment  guidelines.  
SN  - 
PB  - The McGraw-Hill Companies
CY  - New York, NY
Y2  - 2024/04/23
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=7029647
ER  -