TY - CHAP M1 - Book, Section TI - Chapter 408. Disorders of Digestion and Absorption A1 - Hill, Ivor D. A1 - Caicedo, Ricardo A. A2 - Rudolph, Colin D. A2 - Rudolph, Abraham M. A2 - Lister, George E. A2 - First, Lewis R. A2 - Gershon, Anne A. PY - 2011 T2 - Rudolph's Pediatrics, 22e AB - The assimilation of ingested nutrients involves a complex integrated process of digestion and absorption with subsequent transport of the breakdown products across the intestinal mucosa into the systemic circulation. Normal digestion and absorption is discussed in Chapter 381. The term malabsorption is broadly used to characterize abnormalities of both digestion and absorption. The schema in Table 408-1 lists the major pathogenic mechanisms of various specific malabsorptive disorders that are generally due to disorders in luminal digestion, mucosal function, or lymphatic transport. Malabsorption may involve multiple nutrients (as occurs with celiac disease or pancreatic insufficiency) or only a single molecule (as found in isolated glucose-galactose malabsorption or vitamin B12 malabsorption). Defects may be congenital, with onset of symptoms shortly after birth, or acquired, when the age of onset of symptoms is variable. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/04/23 UR - accesspediatrics.mhmedical.com/content.aspx?aid=7037058 ER -