TY - CHAP M1 - Book, Section TI - Chapter 453. Osteosarcoma A1 - Gorlick, Richard A1 - Meyers, Paul A. A2 - Rudolph, Colin D. A2 - Rudolph, Abraham M. A2 - Lister, George E. A2 - First, Lewis R. A2 - Gershon, Anne A. PY - 2011 T2 - Rudolph's Pediatrics, 22e AB - Osteosarcoma is the most common malignant primary bone tumor in children and adolescents.Osteosarcoma’s destruction of normal bone architecture and its production of malignant osteoid can permit its identification from skeletal remains, allowing the recognition that it is an ancient disease. Among the earliest malignant bone tumor described in humans, it was presumed to be identified in the humerus of a male Celt from 800 to 600 BC.1 A probable osteosarcoma dates back to 250 AD in the pelvis of a young individual from Ancient Egypt. A definite osteosarcoma with a classic sunburst appearance was found in the remains of the femur of a Peruvian from approximately 1100 to 1200 AD.1 The term osteosarcoma was introduced by Alexis Boyer (1757–1833), and the first large clinical-pathological description of sarcomas of bone was performed by Samuel Weissel Gross (1837–1889).2 In this description, the tendency for hematogenous and not lymphatic dissemination, as well as the occurrence of skip metastases, led to the suggestion that amputation be performed at a distance beyond the primary lesion.2 SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=7042696 ER -