TY - CHAP M1 - Book, Section TI - Chapter 472. Glomerular Diseases A1 - Eddy, Allison A. A2 - Rudolph, Colin D. A2 - Rudolph, Abraham M. A2 - Lister, George E. A2 - First, Lewis R. A2 - Gershon, Anne A. PY - 2011 T2 - Rudolph's Pediatrics, 22e AB - Glomerular diseases present clinically in several different ways, depending on the nature and severity of the primary disease and the extent to which the normal physiological functions of the glomerulus are perturbed.1,2 Some children with glomerulonephritis (GN) are found incidentally to have microscopic hematuria or proteinuria when checked by routine urinalysis but are otherwise asymptomatic. At the other extreme, children may become critically ill with oligoanuric rapidly progressive GN in need of urgent dialysis. A few glomerular diseases are inherited (see Chapter 473), but most forms of GN are acquired and are generally considered to be immunologically mediated. There are three classical clinical syndromes that develop from glomerular injury: acute and chronic glomerulonephritis, defined by the triad of hematuria, hypertension, and azotemia; nephrotic syndrome, defined by proteinuria and hypoalbuminemia; and hemolytic uremic syndrome, defined by microangiopathic hemolytic anemia, thrombocytopenia, and renal insufficiency. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/10/03 UR - accesspediatrics.mhmedical.com/content.aspx?aid=7045367 ER -