TY - CHAP M1 - Book, Section TI - Chapter 541. Abnormal Pubertal Development A1 - Styne, Dennis M. A1 - Cuttler, Leonna A2 - Rudolph, Colin D. A2 - Rudolph, Abraham M. A2 - Lister, George E. A2 - First, Lewis R. A2 - Gershon, Anne A. PY - 2011 T2 - Rudolph's Pediatrics, 22e AB - Sexual precocity is the general term for early puberty. Isosexual precocity refers to a girl who feminizes or a boy who virilizes early. Central precocious puberty or true precocious puberty is a term reserved for children with gonadotropin-releasing hormone (GnRH)-dependent early puberty that follows the normal pubertal pattern and the normal control mechanisms through GnRH. The only difference from normal puberty is the earlier age at onset. Central precocious puberty can be idiopathic or caused by organic conditions such as a brain tumor or a hamartoma of the tuber cinereum. GnRH-independent isosexual precocity is caused by excessive estrogen secretion in girls or androgen secretion in boys from sources other than the GnRH-gonadotropin axis (such as the gonads, the adrenal glands, ectopic human chorionic gonadotropin (hCG) secretion, and exogenous sources of sex steroids). Gonadotropins are suppressed by negative feedback in all forms of GnRH-independent isosexual precocity because sex steroid secretion is autonomous. Contrasexual (or heterosexual) precocity refers to girls who virilize and boys who feminize. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=7054683 ER -