TY - CHAP M1 - Book, Section TI - Chapter 28. Metabolic and Drug-Induced Liver Disease A1 - O'Connor, Judith A. A2 - Bishop, Warren P. PY - 2010 T2 - Pediatric Practice: Gastroenterology AB - Metabolic liver disease has traditionally referred to diseases that result from inborn errors of metabolism. These disorders are due to a single enzyme defect that affects the synthesis or catabolism of a carbohydrate (CHO), protein, or lipid. These defects in metabolism can result in either liver failure or cirrhosis, with or without injury to other tissues, or relative sparing of the liver with primary toxicity to other organ systems (Table 28–1). Metabolic disorders that arise in the liver with primary toxicity to other organ systems are not addressed in this chapter. This chapter approaches metabolic-induced liver disease not only from the traditional approach, those resulting from a single enzyme defect, but also as a genetic susceptibility induced by a trigger, such as a drug or a metabolic derangement associated with visceral obesity (nonalcoholic fatty liver disease (NAFLD)). SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=55943675 ER -