TY - CHAP M1 - Book, Section TI - Immunology and Transplantation A1 - Rasmussen, Sara K. A1 - Colombani, Paul M. A2 - Ziegler, Moritz M. A2 - Azizkhan, Richard G. A2 - Allmen, Daniel von A2 - Weber, Thomas R. PY - 2014 T2 - Operative Pediatric Surgery, 2e AB - Though nonspecific host defenses are somewhat deficient in the infant and pediatric patient, the effector arm of the specific immunologic response to alloantigens of clinical organ transplants is intact at the time of birth.Effective organ allograft immunosuppression requires a balance of prevention of rejection of the graft while avoiding the toxicity of excessive immunosuppressing agents.Immunosuppressive agents can be categorized into those used for induction (rabbit anti-thymocyte globulin, corticosteroids), those for maintenance (mycophenolate mofetil, tacrolimus), and those used to treat acute rejection (corticosteroids). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/11/02 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1100439958 ER -