TY - CHAP M1 - Book, Section TI - Opioids A1 - Thompson, Trevonne M. A1 - Erickson, Timothy B. A2 - Schafermeyer, Robert A2 - Tenenbein, Milton A2 - Macias, Charles G. A2 - Sharieff, Ghazala Q. A2 - Yamamoto, Loren G. PY - 2014 T2 - Strange and Schafermeyer's Pediatric Emergency Medicine, 4e AB - The classical triad of central nervous system depression, respiratory depression, and pinpoint pupils characterizes opioid toxicity.Some opioids, such as methadone can have delayed or prolonged effects.Opioids can cause acute lung injury or noncardiogenic pulmonary edema in severe overdoses.Toxicity from propoxyphene, meperidine, and tramadol, as well as neonatal opioid withdrawal, can result in seizure activity.Airway management and the use of the pure opioid antagonist naloxone are the mainstays of opioid toxicity treatment. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1105686483 ER -