TY - CHAP M1 - Book, Section TI - Osteopenia of Prematurity A1 - Gomella, Tricia Lacy A1 - Cunningham, M. Douglas A1 - Eyal, Fabien G. A1 - Tuttle, Deborah J. PY - 2013 T2 - Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 7e AB - Prematurity affects bone mineralization and bone growth—thus the entity known as osteopenia of prematurity; however, some authors use the term “rickets of prematurity.” Normal bone is formed by the deposition of minerals, predominantly calcium (Ca+2) and phosphorus (P), onto an organic matrix (osteoid) secreted by the osteoblasts. Osteoclasts play an important role in bone resorption and remodeling. Although osteopenia and rickets result in decreased bone mineralization and may have similar clinical findings, they are not identical processes and thus the term “rickets of prematurity” is not used in this chapter. Osteopenia of prematurity is principally a result of inadequate calcium intake to meet bone growth demands. Rickets, however, is principally due to vitamin D deficiency, but vitamin D supplementation alone will not resolve either osteopenia or rickets. Both disease processes involve the utilization of calcium, phosphorous, and vitamin D. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/10 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1107524712 ER -