TY - CHAP M1 - Book, Section TI - Air Leak Syndromes A1 - Gomella, Tricia Lacy A1 - Cunningham, M. Douglas A1 - Eyal, Fabien G. A1 - Tuttle, Deborah J. PY - 2013 T2 - Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 7e AB - The pulmonary air leak syndromes (pneumomediastinum, pneumothorax, pulmonary interstitial emphysema [PIE], pneumatocele, pneumopericardium, pneumoperitoneum, and pneumoretroperitoneum) comprise a spectrum of diseases with the same underlying pathophysiology. Overdistention of alveolar sacs or terminal airways leads to disruption of airway integrity, resulting in dissection of air into extra-alveolar spaces. Very rarely air can enter pulmonary vasculature (pulmonary veins) and cause air embolus. Air can also leak into the subcutaneous layers of the skin, especially skin of the chest, neck, and face, causing subcutaneous emphysema. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/04 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1107528101 ER -