TY  - CHAP
M1  - Book, Section
TI  - Coagulation Disorders
A1  - Gomella, Tricia Lacy
A1  - Cunningham, M. Douglas
A1  - Eyal, Fabien G.
A1  - Tuttle, Deborah J.
PY  - 2013
T2  - Neonatology: Management, Procedures, On-Call Problems, Diseases, and Drugs, 7e
AB  - Bleeding  and  thrombosis  are  the  2  extremes  of  the  physiological  process  of  coagulation  disorders.  Despite  major  differences  in  the  levels  of  individual  components  of  the  hemostatic  system,  neonatal  coagulation  is  equal  to  or  somewhat  more  rapid  than  that  observed  in  adults.  This  suggests  the  existence  of  a  delicately  balanced  hemostatic  system  in  neonates,  with  uncommon  bleeding  or  thrombosis  in  healthy  term  infants.  However,  a  number  of  perinatal  or  neonatal  conditions  can  disrupt  this  balance  and  increase  the  risk  for  either  hemorrhage  or  thrombus  formation.  The  presence  of  bleeding  in  a  healthy  term  or  late  preterm  infant,  especially  in  an  infant  with  a  normal  platelet  count,  is  strongly  suggestive  of  a  congenital  bleeding  disorder.  Hemophilia  A  and  B  and  von  Willebrand  disease  account  for  95–98%  of  congenital  bleeding  disorders.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/23
UR  - accesspediatrics.mhmedical.com/content.aspx?aid=1107528441
ER  -