TY - CHAP M1 - Book, Section TI - B and T Cell Immunodeficiencies—Severe Combined Immunodeficiency (SCID) and Other Well Defined Primary Immunodeficiencies A1 - Schroer, Brian A1 - Niehues, Tim A1 - Dückers, Gregor A2 - Usatine, Richard P. A2 - Sabella, Camille A2 - Smith, Mindy Ann A2 - Mayeaux, E.J. A2 - Chumley, Heidi S. A2 - Appachi, Elumalai PY - 2015 T2 - The Color Atlas of Pediatrics AB - A 2.5-month-old-baby boy presented to his pediatrician because of a 10-day history of diarrhea, which began soon after his first series of immunizations, which included the oral rotavirus vaccine. He was born via uncomplicated vaginal delivery and his birth weight and height were at the 55 percent percentile. There were no known ill contacts. His weight and height, which had been 15 percent at two months, was now lower and he had a fever to 101F. Thrush was noted on his tongue and throat, and he was noted to have a diffuse scaling rash on the face and hands (Figures 219-1 and 219-2). A CBC with differential showed an absolute lymphocyte count of 1,200 cells/microliter. A chest x-ray was performed which showed diffuse infiltrates and the absence of a thymic shadow. He was referred to an immunologist for immediate evaluation and treatment. T and B cell subsets were obtained, which revealed that 90 percent of his lymphocytes are B cells and that he had very low numbers of T of maternal origin and NK cells. He was treated with intravenous immune globulin (IVIG), placed on trimethoprim-sulfamethoxazole for Pneumocystis jirovecii prophylaxis and referred to a specialized immunology center for a bone marrow transplant. His bone marrow transplantation was successful. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1114880507 ER -