TY - CHAP M1 - Book, Section TI - The Skull and Face A1 - Wells, Robert G. PY - 2015 T2 - Diagnostic Imaging of Infants and Children AB - Craniofacial development initiates at approximately gestation day 25, following closure of the anterior neuropore. Neural crest cells migrate and induce formation of the branchial arches. The first branchial arch and neural crest ectomesenchyme give rise to 5 prominences that surround the stomodeum (the future mouth). The facial prominences (or processes) consist of a single midline frontal prominence (median nasal process), paired maxillary prominences, and paired mandibular prominences. The facial prominences progressively fuse by disintegration of the contacting epithelial surfaces, and the intervening grooves fill in by migration of cells and proliferation of mesenchyme. Formation of the palate involves fusion of the primary palate, which is derived from the median nasal process, and the palatine shelves, which are derived from the maxillary processes. Failure of appropriate fusion of the 7 embryonic facial prominences results in persistent facial or palatal clefts. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1148943761 ER -