TY - CHAP M1 - Book, Section TI - Herpes Simplex Virus A1 - Gutierrez, Kathleen A2 - Stevenson, David K. A2 - Cohen, Ronald S. A2 - Sunshine, Philip PY - 2015 T2 - Neonatology: Clinical Practice and Procedures AB - Neonatal herpes simplex virus (HSV) infection refers to any HSV infection occurring in infants within the first 28 days of life. Most infants present with symptoms within the first 2–3 weeks of life, and some cases are recognized as late as 4–6 weeks of age (rare cases recognized up until 8 weeks of age). Both HSV-1 and HSV-2 cause serious infection in the neonate. If infection is unrecognized and untreated, 50% of infants with central nervous system (CNS) HSV disease and 85% of infants with disseminated HSV infection die by 1 year of age.1 Advances in the diagnosis and treatment of neonatal HSV infection since the mid-1980s have improved the outcomes of infected infants.2 Despite advances in care, there is no evidence that the incidence of infection has decreased. Delay in diagnosis persists, and some infants who survive infection suffer devastating long-term sequelae.2 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/04 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1117368394 ER -