TY - CHAP M1 - Book, Section TI - Thrombocytopenia A1 - Wong, Wendy A1 - Lo, Clara A1 - Glader, Bert A2 - Stevenson, David K. A2 - Cohen, Ronald S. A2 - Sunshine, Philip PY - 2015 T2 - Neonatology: Clinical Practice and Procedures AB - Thrombocytopenia in neonates is defined as a platelet count of less than 150 × 109/L. The prevalence of thrombocytopenia in healthy term infants is 1%–2%, whereas up to 35% of neonates admitted to intensive care units may have low platelet counts.1 There are developmental differences in megakaryopoiesis between neonates and older children. Neonatal megakaryocytes are less capable of upregulating platelet production or mounting as high a level of thrombopoietin (Tpo) when compared to adults with the same degree of thrombocytopenia.2 These developmental differences account for the vulnerability of sick neonates to thrombocytopenia. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accesspediatrics.mhmedical.com/content.aspx?aid=1109798691 ER -