RT Book, Section
A1 Morita, Diego A.
A1 Glauser, Tracy A.
A2 Duchowny, Michael
A2 Cross, J. Helen
A2 Arzimanoglou, Alexis
SR Print(0)
ID 1138410943
T1 Lennox–Gastaut and Related Syndromes
T2 Pediatric Epilepsy
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071496216
LK accesspediatrics.mhmedical.com/content.aspx?aid=1138410943
RD 2024/04/19
AB The  clinical  features  of  the  Lennox–Gastaut  syndrome  (LGS)  have  been  recognized  for  more  than  200  years.  The  current  definition  of  LGS  by  the  International  League  Against  Epilepsy  (ILAE)  classification  is:  "LGS  manifests  itself  in  children  aged  1–8  years,  but  appears  mainly  in  preschool-age  children.  The  most  common  seizure  types  are  tonic-axial,  atonic,  and  absence  seizures,  but  other  types  such  as  myoclonic,  generalized  tonic–clonic  seizures  (GTCS),  or  partial  seizures  are  frequently  associated  with  this  syndrome.  Seizure  frequency  is  high,  and  status  epilepticus  is  frequent  (stuporous  states  with  myoclonias,  tonic,  and  atonic  seizures).  The  electroencephalography  (EEG)  usually  has  abnormal  background  activity,  slow  spike-waves  less  than  3  Hz  and,  often,  multifocal  abnormalities.  During  sleep,  bursts  of  fast  rhythms  (10  Hz)  appear.  In  general,  there  is  mental  retardation.  Seizures  are  difficult  to  control,  and  the  development  is  unfavorable.  In  60%  of  cases,  the  syndrome  occurs  in  children  suffering  from  a  previous  encephalopathy,  but  is  primary  in  other  cases."