RT Book, Section A1 Sarafoglou, Kyriakie A1 Hoffmann, Georg F. A1 Roth, Karl S. SR Print(0) ID 1140313749 T1 Preface T2 Pediatric Endocrinology and Inborn Errors of Metabolism, 2e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071773140 LK accesspediatrics.mhmedical.com/content.aspx?aid=1140313749 RD 2024/03/28 AB This book is designed as a source of practical information for the diagnosis and management of pediatric patients with endocrine diseases and inborn errors of metabolism. From its conception, Pediatric Endocrinology and Inborn Errors of Metabolism (PEIEM) was created with this dual purpose: to be both a comprehensive, clinically-focused medical reference for a broad audience from specialist nurses and general physicians to specialists in each discipline, and to be an information bridge providing inroads into the fundamental concepts of the two interrelated disciplines. The contributors and editorial team strove to make the chapters on inborn errors approachable by endocrinologists and the endocrine chapters approachable by metabolic specialists through what became the underlying precept of the textbook—explanation, not simplification. Following this paradigm, chapters first elucidate the mechanisms underlying a disorder and how they relate to the corresponding phenotypes through clinically relevant discussions of genetics and pathophysiology, thus framing the basis of disease; and second, provide complete and detailed discussions of clinical features, laboratory evaluations, treatment modalities, and follow-up management. Rather than simply listing signs and symptoms under the assumption that their occurrence within a disorder is always self-explanatory, PEIEM explains through the pathophysiology why and how these manifestations occur and how they can be approached, modified, or prevented. As a result of this step-wise approach, we hope that medical professionals at any level involved in caring for endocrine and metabolic patients will find this textbook a useful and comprehensive resource.