RT Book, Section
A1 Gibson, K. Michael
A1 Van Hove, Johan L.K.
A1 Willemsen, Michèl A.A.P.
A1 Hoffmann, Georg F.
A2 Sarafoglou, Kyriakie
A2 Hoffmann, Georg F.
A2 Roth, Karl S.
SR Print(0)
ID 1140324276
T1 Neurotransmitter Disorders
T2 Pediatric Endocrinology and Inborn Errors of Metabolism, 2e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071773140
LK accesspediatrics.mhmedical.com/content.aspx?aid=1140324276
RD 2024/10/11
AB Brain  function  depends  on  the  capacity  of  neurons  within  interconnecting  neuronal  circuitry  to  excite  or  inhibit  one  another.  Excitation  and  inhibition  are  achieved  through  synaptic  transmission,  which  in  turn  is  mediated  by  chemical  messengers  called  neurotransmitters.  Neurotransmission  may  be  thought  of  as  translation  of  an  electrical  signal  to  a  chemical  signal  (mediated  by  the  neurotransmitter)  and  back  to  an  electrical  signal.  In  the  mammalian  brain,  the  primary  excitatory  neurotransmitters  meeting  these  criteria  are  acetylcholine  and  glutamic  acid,  whereas  gamma-aminobutyric  acid  (GABA),  together  with  glycine,  act  as  the  major  inhibitory  neurotransmitters.  The  biogenic  amines  are  also  critically  important  chemical  neurotransmitters.  These  include  the  catecholamines  (ie,  dopamine,  norepinephrine,  and  epinephrine)  and  the  indoleamines  (ie,  serotonin  and  melatonin).