RT Book, Section A1 Stratakis, Constantine A. A1 Pacak, Karel A1 Bauer, Andrew J. A2 Sarafoglou, Kyriakie A2 Hoffmann, Georg F. A2 Roth, Karl S. SR Print(0) ID 1140324479 T1 Endocrine-Related Cancer T2 Pediatric Endocrinology and Inborn Errors of Metabolism, 2e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071773140 LK accesspediatrics.mhmedical.com/content.aspx?aid=1140324479 RD 2024/03/28 AB Thyroid carcinoma is the most common endocrine tumor in children (and in adults); approximately 10% of thyroid cancers are diagnosed before 19 years of age. Similar to adults, the most common presentation is an asymptomatic nodule noted on physical examination; however, thyroid nodules are reported much less frequently in children, and the risk of malignant disease appears to be much higher, with 20% to 25% of pediatric nodules found to have carcinoma compared with 10% to 14% of adults.1 In addition, at diagnosis, approximately 60% of children have regional lymph node metastasis, and up to 15% to 20% with lateral lymph node metastasis will have pulmonary metastasis.2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18