RT Book, Section A1 Nguyen, Trung C. A1 Carcillo, Joseph A. A2 Kline, Mark W. SR Print(0) ID 1182925201 T1 Pathophysiology of Sepsis T2 Rudolph's Pediatrics, 23e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259588594 LK accesspediatrics.mhmedical.com/content.aspx?aid=1182925201 RD 2024/04/25 AB Sepsis continues to be the leading cause of death among children worldwide, accounting for more than 5.9 million deaths per year according to data from the World Health Organization and the United Nations Children’s Fund. In the United States, sepsis poses a significant healthcare burden with approximately 75,000 children admitted annually to hospitals with severe sepsis and an associated cost of $4.8 billion. Understanding the pathophysiology of systemic inflammatory response syndrome (SIRS) and sepsis syndrome is essential for recognition and management of this deadly disease.