RT Book, Section A1 Eble, Tanya N. A1 Nagamani, Sandesh C. S. A2 Kline, Mark W. SR Print(0) ID 1182930509 T1 Principles for the Practice of Clinical Genetics T2 Rudolph's Pediatrics, 23e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259588594 LK accesspediatrics.mhmedical.com/content.aspx?aid=1182930509 RD 2024/10/04 AB Few specialties of medicine, if any, can match the unprecedented advances that have occurred in the field of human and medical genetics during the last 2 decades. Since completion of the sequencing of the human genome in 2003, our understanding of the genetic bases of rare single-gene disorders as well as common multifactorial disorders has increased tremendously. Molecular cytogenetic and sequencing techniques are not only being widely used for diagnosis of many disorders but also to help guide management and therapy, particularly cancer therapy. This chapter outlines the key principles of genetics that are relevant for the practice of medicine.