RT Book, Section
A1 Schleiss, Mark R.
A2 Kline, Mark W.
SR Print(0)
ID 1154127552
T1 Streptococcus Group A Infections
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1154127552
RD 2020/10/28
AB Descriptions  of  what  were  likely  Streptococcus  pyogenes  infections  are  found  in  the  earliest  written  records  of  human  history.  S  pyogenes  was  likely  responsible  for  the  apparent  scarlet  fever  epidemic  described  by  Hippocrates  in  the  5th  century  BC.  The  first  modern  description  of  streptococcal  infection  was  the  demonstration  of  the  organism  in  patients  with  erysipelas  and  wound  infection  in  1874.  The  organism  was  designated  Streptococcus  pyogenes  by  Rosenbach  in  the  late  19th  century.  In  the  early  1930s,  Rebecca  Lancefield’s  classification  of  the  β-hemolytic  strains  into  characteristic  distinct  serogroups  led  to  the  recognition  that  serogroup  A  isolates  (S  pyogenes)  were  the  strains  most  commonly  responsible  for  pharyngitis  and  impetigo/pyoderma.  S  pyogenes  is  one  of  the  most  important  infectious  agents  encountered  in  clinical  practice  causing  infections  of  the  upper  respiratory  tract  and  skin.  S  pyogenes  also  causes  a  variety  of  severe  systemic  infections,  including  toxic  shock  syndrome  and  life-threatening  skin  and  soft  tissue  infections.  Infection  with  this  pathogen  is  also  causally  linked  to  2  serious  nonsuppurative  complications,  acute  rheumatic  fever  and  acute  glomerulonephritis.