RT Book, Section A1 Hay, Jr, William W. A1 Levin, Myron J. A1 Deterding, Robin R. A1 Abzug, Mark J. SR Print(0) ID 1145454915 T1 Cryptorchidism T2 Quick Medical Diagnosis & Treatment Pediatrics YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781264257614 LK accesspediatrics.mhmedical.com/content.aspx?aid=1145454915 RD 2024/03/29 AB Affects 2–4% of full-term male newborns and up to 30% of premature infantsAfter 6 months of age, spontaneous descent occurs only very rarelyCan occur in an isolated fashion or associated with other findingsAbnormalities in the hypothalamic-pituitary-gonadal axis and androgen biosynthesis or receptor defects predispose to cryptorchidismFertility is impaired by approximately 33% after unilateral cryptorchidism and by 66% after bilateral diseaseRisk of cancer in adults with history of cryptorchidism in childhood is reported to be 5–10 times greater than normalHowever, histologic changes clearly occur as early as age 6 months in children with undescended testes