RT Book, Section
A1 Hay, Jr, William W.
A1 Levin, Myron J.
A1 Deterding, Robin R.
A1 Abzug, Mark J.
SR Print(0)
ID 1145454999
T1 Delayed Puberty, Boys
T2 Quick Medical Diagnosis & Treatment Pediatrics
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781264257614
LK accesspediatrics.mhmedical.com/content.aspx?aid=1145454999
RD 2024/10/09
AB Indications  for  evaluationNo  secondary  sexual  characteristics  by  14  years  of  ageMore  than  5  years  have  elapsed  since  the  first  signs  of  puberty  without  completion  of  genital  growthMost  common  cause  is  constitutional  growth  delayHypogonadism  in  boys  may  be  classified  asPrimary  due  to  absence,  malfunction,  or  destruction  of  testicular  tissueCentral  due  to  pituitary  or  hypothalamic  insufficiencyPrimary  testicular  insufficiency  may  be  due  toAnorchiaKlinefelter  syndrome  (47,XXY)  or  other  sex  chromosome  abnormalitiesEnzymatic  defects  in  testosterone  synthesisInflammation  or  destruction  of  the  testes  following  infection  (mumps),  autoimmune  disorders,  radiation,  trauma,  or  tumorCentral  hypogonadism  may  accompanyPanhypopituitarismHypogonadotropic  hypogonadism  with  (Kallmann  syndrome)  or  without  abnormalities  in  smellHyperprolactinemiaIsolated  luteinizing  hormone  (LH)  or  follicle-stimulating  hormone  (FSH)  deficiencyDestructive  lesions  in  or  near  the  anterior  pituitary  (especially  craniopharyngioma  and  glioma)InfectionPrader-Willi  syndromeLaurence-Moon  syndrome  (Bardet-Biedl  syndrome)Deficiencies  in  gonadotropins  may  be  partial  or  completeFunctional  or  reversible  gonadotropin  may  occur  with  chronic  illness,  malnutrition,  hyperprolactinemia,  hypothyroidism,  or  excessive  exercise