RT Book, Section
A1 Hay, Jr, William W.
A1 Levin, Myron J.
A1 Deterding, Robin R.
A1 Abzug, Mark J.
SR Print(0)
ID 1145455144
T1 Disseminated Intravascular Coagulation
T2 Quick Medical Diagnosis & Treatment Pediatrics
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9781264257614
LK accesspediatrics.mhmedical.com/content.aspx?aid=1145455144
RD 2024/04/19
AB Characterized  by  tissue  factor–mediated  coagulation  activation  in  the  patientInvolves  dysregulated,  excessive  thrombin  generation,  with  consequent  intravascular  fibrin  deposition  and  consumption  of  platelets  and  procoagulant  factorsMicrothrombi,  composed  of  fibrin  and  platelets,  may  produce  tissue  ischemia  and  end-organ  damageFibrinolytic  system  is  frequently  activated,  leading  to  plasmin-mediated  destruction  of  fibrin  and  fibrinogen;  this  results  in  fibrin-fibrinogen  degradation  products  (FDPs)  that  exhibit  anticoagulant  and  platelet-inhibitory  functionsDIC  commonly  accompanies  severe  infection  and  other  critical  illnessesConditions  known  to  trigger  DIC  includeEndothelial  damage  (eg,  endotoxin,  virus)Tissue  necrosis  (eg,  burns)Diffuse  ischemic  injury  (eg,  shock,  hypoxia  acidosis)Systemic  release  of  tissue  procoagulants  (eg,  certain  cancers,  placental  disorders)