RT Book, Section A1 Hay, Jr, William W. A1 Levin, Myron J. A1 Deterding, Robin R. A1 Abzug, Mark J. SR Print(0) ID 1145455144 T1 Disseminated Intravascular Coagulation T2 Quick Medical Diagnosis & Treatment Pediatrics YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9781264257614 LK accesspediatrics.mhmedical.com/content.aspx?aid=1145455144 RD 2024/10/14 AB Characterized by tissue factor–mediated coagulation activation in the patientInvolves dysregulated, excessive thrombin generation, with consequent intravascular fibrin deposition and consumption of platelets and procoagulant factorsMicrothrombi, composed of fibrin and platelets, may produce tissue ischemia and end-organ damageFibrinolytic system is frequently activated, leading to plasmin-mediated destruction of fibrin and fibrinogen; this results in fibrin-fibrinogen degradation products (FDPs) that exhibit anticoagulant and platelet-inhibitory functionsDIC commonly accompanies severe infection and other critical illnessesConditions known to trigger DIC includeEndothelial damage (eg, endotoxin, virus)Tissue necrosis (eg, burns)Diffuse ischemic injury (eg, shock, hypoxia acidosis)Systemic release of tissue procoagulants (eg, certain cancers, placental disorders)