RT Book, Section
A1 Karam, Lina Boujaoude
A2 Kline, Mark W.
SR Print(0)
ID 1182909004
T1 Autoimmune Disorders of the Liver
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182909004
RD 2024/10/14
AB Autoimmune  liver  disorders  result  from  a  spectrum  of  immune  dysregulation  where  the  liver  can  be  the  only  organ  affected  or  may  be  part  of  a  systemic  multiorgan  disorder  with  the  inflammatory  response  being  mediated  by  systemic  or  locally  produced  (portal  system)  cytokines.  The  immunogenic  target  varies  and  may  include  the  liver  parenchyma,  bile  duct  epithelium,  or  vasculature,  with  overlap  syndromes  that  include  both  biliary  and  parenchymal  involvement  being  increasingly  recognized  among  children.  Clinical  manifestations  vary  depending  upon  the  pattern  of  involvement.