RT Book, Section A1 Janeway, Katherine A. A1 Gorlick, Richard A2 Kline, Mark W. SR Print(0) ID 1182911310 T1 Osteosarcoma T2 Rudolph's Pediatrics, 23e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259588594 LK accesspediatrics.mhmedical.com/content.aspx?aid=1182911310 RD 2024/10/03 AB Osteosarcoma should be considered in the differential diagnosis of bone pain, as early recognition may increase the likelihood that radiographically visible metastatic disease, which adversely impacts patient prognosis, will not develop between the time of symptom onset and diagnosis. In addition to its importance as a clinical entity, its rigorous study, beginning with an osteosarcoma registry created under the auspices of the American College of Surgeons in 1921, highlights important oncologic principles, including the concept of microscopic metastatic disease and the role of adjuvant therapy.