RT Book, Section
A1 Ganem, Jorge F.
A2 Zaoutis, Lisa B.
A2 Chiang, Vincent W.
SR Print(0)
ID 1146119871
T1 Interstitial Nephritis
T2 Comprehensive Pediatric Hospital Medicine, 2e
YR 2017
FD 2017
PB McGraw-Hill Education
PP New York, NY
SN 9780071829281
LK accesspediatrics.mhmedical.com/content.aspx?aid=1146119871
RD 2024/04/19
AB Interstitial  nephritis  was  first  described  histologically  in  1898  in  the  kidneys  of  patients  who  died  from  diphtheria  and  scarlet  fever.1  Interstitial  nephritis  is  characterized  by  histologic  changes  due  to  infiltration  of  the  renal  interstitium  and  tubular  cells  by  inflammatory  cells  accompanied  by  interstitial  edema  or  fibrosis  and  varying  degrees  of  tubular  atrophy.  These  inflammatory  changes  usually  spare  the  glomeruli  and  renal  vasculature.  Interstitial  nephritis  is  now  termed  tubulointerstitial  nephritis  (TIN).  Acute  TIN  refers  to  acute  renal  dysfunction  and  is  usually  reversible.  Common  types  of  acute  TIN  include  drug  induced,  infectious,  immune  mediated,  and  idiopathic.