RT Book, Section A1 Hoffman, Robert J. A1 Sharma, Adhi N. A2 Zaoutis, Lisa B. A2 Chiang, Vincent W. SR Print(0) ID 1146123968 T1 Withdrawal Syndromes T2 Comprehensive Pediatric Hospital Medicine, 2e YR 2017 FD 2017 PB McGraw-Hill Education PP New York, NY SN 9780071829281 LK accesspediatrics.mhmedical.com/content.aspx?aid=1146123968 RD 2024/03/28 AB Drug withdrawal is a physiologic response to an effectively lowered drug concentration in a patient tolerant to the drug in question. Withdrawal results in a predictable constellation of symptoms that are reversible if the drug is reintroduced. Withdrawal is a phenomenon of altered neurochemistry, and the central nervous system (CNS) is the most consequential target. Under normal conditions, the CNS maintains a balance between excitation and inhibition. Although such balance can be achieved by several means, excitation is constant and actions occur through removal of inhibitory tone.1