RT Book, Section A1 Van Hove, Johan L. K. A2 Kline, Mark W. SR Print(0) ID 1182928451 T1 Disorders of Glycine Metabolism T2 Rudolph's Pediatrics, 23e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259588594 LK accesspediatrics.mhmedical.com/content.aspx?aid=1182928451 RD 2024/11/04 AB Formation and elimination of glycine occur through many pathways. One precursor of glycine is choline, which can be oxidized to betaine and sequentially demethylated to dimethylglycine, sarcosine, and glycine, which is finally degraded to CO2 and NH3. Different defects in glycine metabolism lead to distinct biochemical or clinical phenotypes.