RT Book, Section
A1 Van Hove, Johan L. K.
A2 Kline, Mark W.
SR Print(0)
ID 1182928451
T1 Disorders of Glycine Metabolism
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182928451
RD 2024/04/16
AB Formation  and  elimination  of  glycine  occur  through  many  pathways.  One  precursor  of  glycine  is  choline,  which  can  be  oxidized  to  betaine  and  sequentially  demethylated  to  dimethylglycine,  sarcosine,  and  glycine,  which  is  finally  degraded  to  CO2  and  NH3.  Different  defects  in  glycine  metabolism  lead  to  distinct  biochemical  or  clinical  phenotypes.