RT Book, Section A1 Riedl, Marc A. A2 Kline, Mark W. SR Print(0) ID 1182931856 T1 Anaphylaxis, Urticaria, and Angioedema T2 Rudolph's Pediatrics, 23e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259588594 LK accesspediatrics.mhmedical.com/content.aspx?aid=1182931856 RD 2024/10/05 AB Anaphylaxis, urticaria, and angioedema frequently share a common pathophysiology in that these conditions most commonly result from immunoglobulin E (IgE)-mediated mast cell activation, resulting in the release of histamine, leukotrienes, and other mast cell mediators. Urticaria and angioedema are isolated to mucocutaneous symptoms, whereas anaphylaxis is an acute systemic reaction that may rapidly lead to cardiopulmonary collapse.