RT Book, Section
A1 Punia, Jyotinder Nain
A1 Elghetany, M. Tarek
A2 Kline, Mark W.
SR Print(0)
ID 1182909587
T1 Hematopoiesis
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182909587
RD 2024/04/20
AB The  bone  marrow,  one  of  the  largest  organs  in  the  human  body,  accomplishes  the  enormous  and  complex  task  of  blood  cell  production.  In  adults,  the  marrow  produces  2.5  billion  red  cells,  2.5  billion  platelets,  and  1  billion  granulocytes  per  kilogram  of  body  weight  on  a  daily  basis.  Blood  cell  production,  which  can  increase  up  to  30-fold,  depending  upon  increased  peripheral  demand  or  increased  destruction,  is  mediated  by  complex  interactions  of  marrow  stem  cells  with  stromal  cells,  hematopoietic  growth  factors,  and  interleukins.  This  chapter  provides  an  overview  of  the  developmental  changes  in  hematopoiesis  that  occur  from  embryonic  development  through  adolescence,  addressing  changes  in  the  sites  of  hematopoiesis,  components  of  peripheral  blood,  and  the  type  of  hemoglobin  that  is  produced.