RT Book, Section A1 Rizzo, William B. A2 Kline, Mark W. SR Print(0) ID 1182929013 T1 Disorders of Leukotriene Synthesis and Degradation T2 Rudolph's Pediatrics, 23e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259588594 LK accesspediatrics.mhmedical.com/content.aspx?aid=1182929013 RD 2024/10/11 AB Leukotrienes (LTs) are inflammatory lipid mediators synthesized from arachidonic acid (C20:4), a 20-carbon polyunsaturated fatty acid that is present in membrane phospholipids. LTs consist of several biochemically distinct forms (LTA4, LTB4, LTC4, LTD4, LTE4) that act through interactions with specific cellular receptors. LTC4, LTD4, and LTE4 are distinct from the other LT species because they are formed by the incorporation of cysteine into their structures and are referred to as cysteinyl-LTs. These lipid mediators are biologically active in allergic and immune reactions, bronchoconstriction, neutrophil and macrophage chemotaxis, and T-cell differentiation. Emerging data also implicate their involvement in neurologic processes.