RT Book, Section
A1 Rizzo, William B.
A2 Kline, Mark W.
SR Print(0)
ID 1182929013
T1 Disorders of Leukotriene Synthesis and Degradation
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182929013
RD 2024/04/24
AB Leukotrienes  (LTs)  are  inflammatory  lipid  mediators  synthesized  from  arachidonic  acid  (C20:4),  a  20-carbon  polyunsaturated  fatty  acid  that  is  present  in  membrane  phospholipids.  LTs  consist  of  several  biochemically  distinct  forms  (LTA4,  LTB4,  LTC4,  LTD4,  LTE4)  that  act  through  interactions  with  specific  cellular  receptors.  LTC4,  LTD4,  and  LTE4  are  distinct  from  the  other  LT  species  because  they  are  formed  by  the  incorporation  of  cysteine  into  their  structures  and  are  referred  to  as  cysteinyl-LTs.  These  lipid  mediators  are  biologically  active  in  allergic  and  immune  reactions,  bronchoconstriction,  neutrophil  and  macrophage  chemotaxis,  and  T-cell  differentiation.  Emerging  data  also  implicate  their  involvement  in  neurologic  processes.