RT Book, Section A1 Sullivan, Kathleen E. A2 Kline, Mark W. SR Print(0) ID 1182931515 T1 Overview of the Immune System T2 Rudolph's Pediatrics, 23e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259588594 LK accesspediatrics.mhmedical.com/content.aspx?aid=1182931515 RD 2024/03/28 AB Our immune system has evolved to provide protection from the pathogens that inhabit the natural world, and a critical aspect of immunologic function is the distinction between self tissues and non-self tissues. Self tissues must not become a target for immune responses, and training to protect self tissues is the essence of tolerance. Our host defense includes barrier functions, and we now know that the barrier interacts dynamically with the cells of the immune system as part of this defense. In this overview, we will describe the elements of the immune system, the development of different functional arms of the immune system, and the beautiful choreography that is intrinsic to an immune response.