RT Book, Section A1 Murray, Thomas S. A1 Baltimore, Robert S. A2 Kline, Mark W. SR Print(0) ID 1182933963 T1 Bacterial Infections of the Central Nervous System T2 Rudolph's Pediatrics, 23e YR 2018 FD 2018 PB McGraw-Hill Education PP New York, NY SN 9781259588594 LK accesspediatrics.mhmedical.com/content.aspx?aid=1182933963 RD 2024/03/29 AB Meningitis, an infection of the subarachnoid space and leptomeninges caused by a variety of pathogenic organisms, continues to be an important source of mortality and morbidity. Despite the introduction of new vaccines that prevent the most severe causes, bacterial or purulent meningitis remains the most important form of meningitis in the United States in terms of incidence, sequelae, and ultimate loss of productive life. Aseptic meningitis, usually caused by viruses, especially enteroviruses, is more common; however, significant sequelae are uncommon, and the disease is usually self-limited. Granulomatous meningitis, caused either by Mycobacterium tuberculosis or fungi, is a major cause of neurologic injury and death in the developing world.