RT Book, Section
A1 El-Hattab, Ayman W.
A1 Scaglia, Fernando
A2 Kline, Mark W.
SR Print(0)
ID 1182930379
T1 Disorders of Purine and Pyrimidine Metabolism
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182930379
RD 2024/04/19
AB Purines  (adenine  and  guanine)  and  pyrimidines  (thymine,  cytosine,  and  uracil)  are  nitrogenous  bases  that  are  essential  components  of  nucleotides.  The  addition  of  pentose  monosaccharide  (ribose  or  deoxyribose)  to  a  base  results  in  a  nucleoside,  which  can  be  a  ribonucleoside  (adenosine,  guanosine,  cytidine,  and  uridine)  or  a  deoxyribonucleoside  (deoxyadenosine,  deoxyguanosine,  deoxycytidine,  and  thymidine).  Nucleotides  result  from  the  binding  of  nucleosides  to  phosphate.  The  binding  of  a  nucleoside  to  1,  2,  or  3  phosphate  groups  produces  nucleoside  mono-,  di-,  or  triphosphate,  respectively.  Nucleotides  are  essential  for  all  cells.  In  addition  to  their  vital  role  as  building  blocks  for  DNA  and  RNA,  they  serve  as  carriers  of  activated  intermediates  in  the  synthesis  of  a  variety  of  complex  molecules,  structural  components  of  several  essential  coenzymes,  messengers  in  signal  transduction  pathways,  regulatory  components  for  many  of  the  metabolic  pathways,  and  currency  for  energy  transfer  in  cells.