RT Book, Section
A1 Poole, Claudette L.
A1 Kimberlin, David W.
A2 Kline, Mark W.
SR Print(0)
ID 1182903284
T1 Herpes Simplex Virus Infections
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182903284
RD 2024/04/17
AB Herpes  simplex  virus  types  1  (HSV-1)  and  2  (HSV-2)  are  2  of  the  8  members  of  the  human  herpesvirus  family.  Along  with  varicella-zoster  virus  (VZV),  HSV-1  and  HSV-2  belong  to  the  alpha-herpesvirus  subfamily  and  share  the  characteristic  neurotropism  and  establishment  of  latency  in  sensory  ganglia,  with  lifelong  infection,  periodic  reactivation,  and  reappearance  of  infectious  virus  at  mucocutaneous  sites.  Clinical  manifestations  when  present  can  range  from  minor  mucocutaneous  vesicles  to  hemorrhagic  encephalitis  or  disseminated  disease,  but  most  persons  infected  with  either  HSV-1  or  HSV-2  are  asymptomatic  (Table  304-1).