RT Book, Section
A1 Schleiss, Mark R.
A2 Kline, Mark W.
SR Print(0)
ID 1182903414
T1 Human Herpesvirus 8 (Kaposi Sarcoma Herpesvirus)
T2 Rudolph's Pediatrics, 23e
YR 2018
FD 2018
PB McGraw-Hill Education
PP New York, NY
SN 9781259588594
LK accesspediatrics.mhmedical.com/content.aspx?aid=1182903414
RD 2024/04/23
AB The  history  of  the  identification  of  human  herpesvirus-8  (HHV-8;  also  known  as  Kaposi  sarcoma  herpesvirus  [KSHV]  or  Kaposi  sarcoma  [KS]  virus)  is  unique  insofar  as  the  virus  was  initially  “discovered”  purely  with  the  use  of  molecular  detection  techniques  and  not  traditional  viral  cell  culture.  On  sequence  analysis  of  tissues  amplified  from  KS  patients,  the  deduced  amino  acid  sequences  were  found  to  have  strong  homology  to  proteins  from  the  gamma-herpesvirus  subfamily,  the  subfamily  of  the  Herpesviridae  that  includes  Epstein-Barr  virus  (EBV).  This  observation  was  striking  in  view  of  the  known  ability  of  EBV  to  persist  in  lymphocytes,  immortalize  cells,  and  produce  human  malignancies  (eg,  Burkitt  lymphoma  and  nasopharyngeal  carcinoma).  Hence,  the  novel  gamma-herpesvirus,  HHV-8,  appeared  to  be  a  new  herpesvirus  associated  with  human  malignancy—KS.